内侧听觉丘脑核是眨眼条件反射所必需的。
Medial auditory thalamic nuclei are necessary for eyeblink conditioning.
作者信息
Halverson Hunter E, Freeman John H
机构信息
Department of Psychology, University of Iowa, Iowa City, IA 52242, USA.
出版信息
Behav Neurosci. 2006 Aug;120(4):880-7. doi: 10.1037/0735-7044.120.4.880.
Abstract
The auditory conditioned stimulus (CS) pathway that is necessary for delay eyeblink conditioning was investigated with induced lesions of the medial auditory thalamus contralateral to the trained eye in rats. Rats were given unilateral lesions of the medial auditory thalamus or a control surgery followed by twenty 100-trial sessions of delay eyeblink conditioning with a tone CS and then five sessions of delay conditioning with a light CS. Rats that had complete lesions of the contralateral medial auditory thalamic nuclei, including the medial division of the medial geniculate, suprageniculate, and posterior intralaminar nucleus, showed a severe deficit in conditioning with the tone CS. Rats with complete lesions also showed no cross-modal facilitation (savings) when switched to the light CS. The medial auditory thalamic nuclei may modulate activity in a short-latency auditory CS pathway or serve as part of a longer latency auditory CS pathway that is necessary for eyeblink conditioning.
摘要
通过对大鼠训练眼对侧的内侧听觉丘脑进行诱导性损伤，研究了延迟眨眼条件反射所必需的听觉条件刺激（CS）通路。给大鼠进行内侧听觉丘脑的单侧损伤或对照手术，随后进行20次每次100次试验的延迟眨眼条件反射，条件刺激为音调，然后进行5次以光为条件刺激的延迟条件反射。对侧内侧听觉丘脑核完全损伤的大鼠，包括内侧膝状体的内侧部、上膝状体和后内侧核，在音调条件刺激的条件反射中表现出严重缺陷。完全损伤的大鼠在转换为光条件刺激时也没有出现跨模态促进（节省）现象。内侧听觉丘脑核可能调节短潜伏期听觉CS通路的活动，或作为眨眼条件反射所必需的较长潜伏期听觉CS通路的一部分。
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