小脑失活会损害眨眼条件反射的跨模态记忆节省。
Cerebellar inactivation impairs cross modal savings of eyeblink conditioning.
作者信息
Campolattaro Matthew M, Freeman John H
机构信息
Department of Psychology, University of Iowa, Iowa City, IA 52242, USA.
出版信息
Behav Neurosci. 2009 Apr;123(2):292-302. doi: 10.1037/a0014483.
Eyeblink conditioning using a conditioned stimulus (CS) from one sensory modality (e.g., an auditory CS) is greatly enhanced when the subject is previously trained with a CS from a different sensory modality (e.g., a visual CS). The enhanced acquisition to the second modality CS results from cross modal savings. The current study was designed to examine the role of the cerebellum in establishing cross modal savings in eyeblink conditioning with rats. In the first experiment rats were given paired or unpaired presentations with a CS (tone or light) and an unconditioned stimulus. All rats were then given paired training with a different modality CS. Only rats given paired training showed cross modal savings to the second modality CS. Experiment 2 showed that cerebellar inactivation during initial acquisition to the first modality CS completely prevented savings when training was switched to the second modality CS. Experiment 3 showed that cerebellar inactivation during initial cross modal training also prevented savings to the second modality stimulus. These results indicate that the cerebellum plays an essential role in establishing cross modal savings of eyeblink conditioning.
当受试者先前接受来自不同感觉模态的条件刺激（CS）（例如视觉CS）训练时，使用来自一种感觉模态的条件刺激（CS）（例如听觉CS）进行的眨眼条件反射会大大增强。对第二种模态CS的增强习得源于跨模态节省。本研究旨在探讨小脑在大鼠眨眼条件反射中建立跨模态节省方面的作用。在第一个实验中，给大鼠呈现CS（音调或灯光）和无条件刺激的配对或非配对刺激。然后对所有大鼠进行不同模态CS的配对训练。只有接受配对训练的大鼠对第二种模态CS表现出跨模态节省。实验2表明，在最初对第一种模态CS的习得过程中小脑失活，当训练切换到第二种模态CS时，完全阻止了节省效应。实验3表明，在最初的跨模态训练过程中小脑失活也阻止了对第二种模态刺激的节省效应。这些结果表明，小脑在建立眨眼条件反射的跨模态节省中起着至关重要的作用。
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