Baird John-Paul, Gray Nora E, Fischer Shannon G
Department of Psychology, Amherst College, Amherst, MA 01002, USA.
Behav Neurosci. 2006 Aug;120(4):937-51. doi: 10.1037/0735-7044.120.4.937.
The effects of intracerebroventricular application of Neuropeptide Y (NPY) on licking microstructure for sucrose, saccharin, and water solutions were evaluated. In Experiment 1, NPY increased meal size for three sucrose concentrations (0.03 M, 0.3 M, and 1.0 M) by increasing licking burst number but not size and by extending meals more than four-fold in duration with a slow, sustained rate of ingestion in late phases of the meal. Results are consistent with the interpretation that NPY suppressed inhibitory postingestive feedback. Experiment 2 supported this conclusion. NPY significantly increased the number of meals initiated for water, 0.1% saccharin, and 1.0 M sucrose solutions, but meal size was only increased for 1.0 M sucrose. Therefore, NPY also increased appetitive feeding behaviors, but its consummatory effects were limited to caloric solutions. The results are discussed with regard to their potential to explain current discrepancies in the literature.
评估了脑室内注射神经肽Y（NPY）对蔗糖、糖精和水溶液舔舐微观结构的影响。在实验1中，NPY通过增加舔舐爆发次数而非大小，以及在进食后期以缓慢、持续的摄取速率将进食时间延长四倍以上，从而增加了三种蔗糖浓度（0.03 M、0.3 M和1.0 M）的进食量。结果与NPY抑制消化后抑制性反馈的解释一致。实验2支持了这一结论。NPY显著增加了对水、0.1%糖精和1.0 M蔗糖溶液开始进食的次数，但进食量仅在1.0 M蔗糖时增加。因此，NPY也增加了食欲性进食行为，但其消耗性作用仅限于含热量的溶液。讨论了这些结果解释文献中当前差异的可能性。
