Limebeer Cheryl L, Parker Linda A
Department of Psychology, Wilfrid Laurier University, Waterloo, ON, Canada.
Behav Neurosci. 2006 Aug;120(4):963-9. doi: 10.1037/0735-7044.120.4.963.
Here the authors evaluated the effect of the method of conditioning (bottle or intraoral [IO] infusion) on the strength of a flavor-drug association when measured in a standard 1-bottle consumption test or when measured by IO infusion in a taste reactivity test. When tested with the bottle test in Experiment 1, rats conditioned by bottle displayed stronger taste avoidance than those conditioned by IO infusion. When tested for rejection reactions with the taste reactivity test in Experiment 2, rats conditioned by infusion displayed a stronger aversion than did rats conditioned by bottle. The results suggest that when the contextual cues of conditioning are similar at conditioning and testing, a stronger association is evident regardless of the individual specifics of each method. These results may shed light on recent reports that different neural mechanisms are involved in conditioning by active consumption and passive infusion.
在此，作者评估了条件化方法（奶瓶或口腔内[IO]灌注）对在标准单瓶消耗试验中测量或在味觉反应性试验中通过IO灌注测量时味道-药物关联强度的影响。在实验1中用奶瓶试验进行测试时，通过奶瓶进行条件化的大鼠比通过IO灌注进行条件化的大鼠表现出更强的味觉回避。在实验2中用味觉反应性试验测试排斥反应时，通过灌注进行条件化的大鼠比通过奶瓶进行条件化的大鼠表现出更强的厌恶。结果表明，当条件化的情境线索在条件化和测试时相似时，无论每种方法的具体细节如何，都会有更强的关联。这些结果可能有助于解释最近的报道，即主动消耗和被动灌注的条件化涉及不同的神经机制。
