严重呼吸道合胞病毒相关疾病患儿黏附分子的基因多态性
Genetic polymorphisms of adhesion molecules in children with severe RSV-associated diseases.
作者信息
Krueger M, Puthothu B, Heinze J, Forster J, Heinzmann A
机构信息
University Children's Hospital, University of Freiburg, Mathildenstrasse 1, D-79106 Freiburg, Germany.
出版信息
Int J Immunogenet. 2006 Aug;33(4):233-5. doi: 10.1111/j.1744-313X.2006.00603.x.
Abstract
Adhesion molecules are involved in the pathophysiology of respiratory syncytial virus (RSV)-associated diseases. By testing polymorphisms within ICAM-1, VCAM-1 and E-selectin, we found no evidence for association of any polymorphism with severe RSV infections. Thus, we conclude that these genes do not predispose to severe RSV-associated diseases.
摘要
黏附分子参与了呼吸道合胞病毒（RSV）相关疾病的病理生理过程。通过检测细胞间黏附分子-1（ICAM-1）、血管细胞黏附分子-1（VCAM-1）和E-选择素中的多态性，我们没有发现任何多态性与严重RSV感染相关的证据。因此，我们得出结论，这些基因不会导致严重的RSV相关疾病。
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