Buchsbaum Monte S, Friedman Joseph, Buchsbaum Bradley R, Chu King-Wai, Hazlett Erin A, Newmark Randall, Schneiderman Jason S, Torosjan Yuliya, Tang Cheuk, Hof Patrick R, Stewart Daniel, Davis Kenneth L, Gorman Jack
Neuroscience Positron Emission Tomography Laboratory, Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029, USA.
Biol Psychiatry. 2006 Dec 1;60(11):1181-7. doi: 10.1016/j.biopsych.2005.11.028. Epub 2006 Aug 7.
Alignment of white matter axons as inferred from diffusion tensor imaging has indicated changes in schizophrenia in frontal and frontotemporal white matter.
Diffusion tensor anisotropy and anatomical magnetic resonance images were acquired in 64 patients with schizophrenia and 55 normal volunteers. Anatomical images were acquired with a magnetization prepared rapid gradient echo sequence, and diffusion tensor images used a pulsed gradient spin-echo acquisition. Images were aligned and warped to a standard brain, and anisotropy in normal volunteers and patients was compared using significance probability mapping.
Patients showed widespread areas of reduced anisotropy, including the frontal white matter, the corpus callosum, and the frontal longitudinal fasciculus.
These findings, which are consistent with earlier reports of frontal decreases in anisotropy, demonstrate that the effects are most prominent in frontal and callosal areas and are particularly widespread in frontal white matter regions.
从扩散张量成像推断的白质轴突排列显示，精神分裂症患者额叶和额颞叶白质发生了变化。
对64例精神分裂症患者和55名正常志愿者进行了扩散张量各向异性和解剖磁共振成像检查。解剖图像采用磁化准备快速梯度回波序列采集，扩散张量图像采用脉冲梯度自旋回波采集。将图像对齐并扭曲到标准脑，使用显著性概率映射比较正常志愿者和患者的各向异性。
患者显示出广泛的各向异性降低区域，包括额叶白质、胼胝体和额纵束。
这些发现与早期关于额叶各向异性降低的报道一致，表明这种影响在额叶和胼胝体区域最为显著，并且在额叶白质区域尤为广泛。
