Kim Gwang-Won, Kim Yun-Hyeon, Jeong Gwang-Woo
Research Institute for Medical Imaging, Chonnam National University Medical School, Gwangju, Republic of Korea.
Department of Radiology, Chonnam National University Medical School, Chonnam National University Hospital, Gwangju, Republic of Korea.
PLoS One. 2017 May 17;12(5):e0177251. doi: 10.1371/journal.pone.0177251. eCollection 2017.
The purpose of this study was to evaluate gray matter (GM) and white matter (WM) volume alterations in whole-brain structures in patients with schizophrenia and healthy controls using voxel-based morphometry (VBM), and further to assess the correlation between GM and WM volume variations and symptom severity in schizophrenia. A total of 22 patients with schizophrenia and 22 age-matched healthy controls participated. Magnetic resonance image data were processed using SPM8 software with diffeomorphic anatomical registration via an exponentiated Lie algebra (DARTEL) algorithm. Patients with schizophrenia exhibited significantly decreased GM volumes of the insula, superior temporal gyrus (STG), gyrus rectus, and anterior cingulate cortex (ACC) compared with healthy controls. The GM volumes of the STG and gyrus rectus were negatively correlated with the positive scales on the Positive and Negative Syndrome Scale (PANSS) and those of the STG and ACC were negatively correlated with the negative scales. The durations of illness in schizophrenia were negatively correlated with the GM volumes of the insula, STG, and ACC. Patients with schizophrenia exhibited significantly decreased WM volumes of the superior frontal gyrus, inferior temporal gyrus, and STG. The WM volumes of the STG were negatively correlated with the duration of illness. Our findings suggest that GM and WM volume abnormalities in the STG are associated with the psychopathology of schizophrenia.
本研究旨在采用基于体素的形态学测量（VBM）方法，评估精神分裂症患者与健康对照者全脑结构中的灰质（GM）和白质（WM）体积变化，并进一步评估精神分裂症患者GM和WM体积变化与症状严重程度之间的相关性。共有22例精神分裂症患者和22例年龄匹配的健康对照者参与研究。磁共振图像数据使用SPM8软件，通过指数李代数（DARTEL）算法进行同胚解剖配准处理。与健康对照者相比，精神分裂症患者的岛叶、颞上回（STG）、直回和前扣带回皮质（ACC）的GM体积显著减少。STG和直回的GM体积与阳性和阴性症状量表（PANSS）的阳性量表呈负相关，STG和ACC的GM体积与阴性量表呈负相关。精神分裂症的病程与岛叶、STG和ACC的GM体积呈负相关。精神分裂症患者的额上回、颞下回和STG的WM体积显著减少。STG的WM体积与病程呈负相关。我们的研究结果表明，STG中的GM和WM体积异常与精神分裂症的精神病理学有关。
