痉挛性截瘫评定量表（SPRS）：一种可靠且有效的疾病严重程度测量方法。

The Spastic Paraplegia Rating Scale (SPRS): a reliable and valid measure of disease severity.

作者信息

Schüle R, Holland-Letz T, Klimpe S, Kassubek J, Klopstock T, Mall V, Otto S, Winner B, Schöls L

机构信息

Hertie Institute for Clinical Brain Research and Department of Neurology, Eberhard Karls University Tübingen, Germany.

出版信息

Neurology. 2006 Aug 8;67(3):430-4. doi: 10.1212/01.wnl.0000228242.53336.90.

DOI:10.1212/01.wnl.0000228242.53336.90

PMID:16894103

Abstract

OBJECTIVE

To develop and evaluate a clinical Spastic Paraplegia Rating Scale (SPRS) to measure disease severity and progression.

METHODS

A 13-item scale was designed to rate functional impairment occurring in pure forms of spastic paraplegia (SP). Additional symptoms constituting a complicated form of SP are recorded in an inventory. Two independent patient cohorts were evaluated in a two-step validation procedure.

RESULTS

Application of SPRS requires less than 15 minutes and does not require any special equipment, so it is suitable for an outpatient setting. Interrater agreement of SPRS was high (intraclass correlation coefficient = 0.99). Reliability was further supported by high internal consistency (Cronbach alpha = 0.91). SPRS values were almost normally distributed without apparent floor or ceiling effect. Construct validity was shown by high correlation of SPRS to Barthel Index and the International Cooperative Ataxia Rating Scale (convergent validity) and low correlation to Mini-Mental Status Examination (discriminant validity).

CONCLUSION

The Spastic Paraplegia Rating Scale is a reliable and valid measure of disease severity.

摘要

目的

开发并评估一种临床痉挛性截瘫评定量表（SPRS），以测量疾病的严重程度和进展情况。

方法

设计了一个包含13个条目的量表，用于对单纯型痉挛性截瘫（SP）所出现的功能损害进行评分。构成复杂型SP的其他症状记录在一份清单中。在一个两步验证程序中对两个独立的患者队列进行了评估。

结果

应用SPRS所需时间不到15分钟，且不需要任何特殊设备，因此适用于门诊环境。SPRS的评分者间一致性较高（组内相关系数 = 0.99）。高内部一致性（Cronbach α = 0.91）进一步支持了其可靠性。SPRS值几乎呈正态分布，无明显的地板效应或天花板效应。SPRS与巴氏指数和国际合作共济失调评定量表的高相关性（收敛效度）以及与简易精神状态检查表的低相关性（区分效度）表明了其结构效度。