Kurtenbach Klaus, Hanincová Klára, Tsao Jean I, Margos Gabriele, Fish Durland, Ogden Nicholas H
Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath, BA2 7AY, UK.
Nat Rev Microbiol. 2006 Sep;4(9):660-9. doi: 10.1038/nrmicro1475. Epub 2006 Aug 7.
The evolutionary ecology of many emerging infectious diseases, particularly vector-borne zoonoses, is poorly understood. Here, we aim to develop a biological, process-based framework for vector-borne zoonoses, using Borrelia burgdorferi sensu lato (s.l.), the causative agent of Lyme borreliosis in humans, as an example. We explore the fundamental biological processes that operate in this zoonosis and put forward hypotheses on how extrinsic cues and intrinsic dynamics shape B. burgdorferi s.l. populations. Additionally, we highlight possible epidemiological parallels between B. burgdorferi s.l. and other vector-borne zoonotic pathogens, including West Nile virus.
许多新发传染病，尤其是媒介传播的人畜共患病的进化生态学，目前仍知之甚少。在此，我们旨在以引起人类莱姆病的伯氏疏螺旋体复合群（Borrelia burgdorferi sensu lato，s.l.）为例，建立一个基于生物学过程的媒介传播人畜共患病框架。我们探究了在这种人畜共患病中起作用的基本生物学过程，并就外部线索和内在动态如何塑造伯氏疏螺旋体复合群种群提出假设。此外，我们强调了伯氏疏螺旋体复合群与其他媒介传播的人畜共患病原体（包括西尼罗河病毒）之间可能存在的流行病学相似之处。
