Davey G, Bradstock K F, Kefford R F, Wishart Y, Kabral A, Grimsley P, Hughes W G
Department of Haematology, Westmead Hospital, N.S.W., Australia.
Leuk Res. 1990;14(1):77-83. doi: 10.1016/0145-2126(90)90149-4.
Thirty-two cases of acute myeloid leukaemia (AML) were examined for expression of terminal deoxynucleotidyl transferase (TdT) and rearrangements of the genes coding for the immunoglobulin heavy chain and the beta chain of the T cell receptor, in order to establish whether these two forms of lineage infidelity are linked. In 17 cases of AML with greater than or equal to 10% TdT+ cells, three cases showed evidence of gene rearrangement, two having clonal rearrangements in the immunoglobulin gene and one with a rearranged T cell receptor gene. Among 15 AML cases without significant numbers of TdT-positive blasts, three cases had rearrangements in both immunoglobulin and T cell receptor genes, while a fourth case had an immunoglobulin gene rearrangement. No relationship was seen between lymphoid gene rearrangements and expression of the lymphoid surface antigens CD7 and CD10. The lack of association between TdT expression and gene rearrangements does not support the concept of an orderly activation of the recombinase machinery in those cases of AML with features of early lymphoid differentiation.
检测了32例急性髓系白血病（AML）患者的末端脱氧核苷酸转移酶（TdT）表达以及编码免疫球蛋白重链和T细胞受体β链的基因重排，以确定这两种谱系不忠实形式是否相关。在17例TdT+细胞≥10%的AML患者中，3例有基因重排证据，2例免疫球蛋白基因有克隆性重排，1例T细胞受体基因重排。在15例TdT阳性原始细胞数量不多的AML患者中，3例免疫球蛋白和T细胞受体基因均有重排，而第4例有免疫球蛋白基因重排。未发现淋巴样基因重排与淋巴样表面抗原CD7和CD10的表达之间存在关联。TdT表达与基因重排之间缺乏相关性，不支持在具有早期淋巴样分化特征的AML病例中重组酶机制有序激活的概念。
