Norton J D, Campana D, Hoffbrand A V, Janossy G, Coustan-Smith E, Jani H, Yaxley J C, Prentice H G
Department of Haematology, Royal Free Hospital and School of Medicine, London, U.K.
Leukemia. 1987 Nov;1(11):757-61.
Ten cases of adult acute myeloid leukemia (AML) displaying lymphoid-associated markers CD7 and/or terminal deoxynucleotidyl transferase (TdT) have been investigated for rearrangement of immunoglobulin and T cell antigen receptor beta and gamma genes. Two of six TdT+ cases had clonally rearranged Ig genes, whereas six of eight CD7+ AMLs, including three that were TdT+, had a germ line configuration of both immunoglobulin and T cell receptor beta and gamma genes. A single case of CD7+ TdT- AML had clonal rearrangement of all three genes. These results indicate that expression of TdT and/or CD7 is not accompanied by gene rearrangement in most cases of adult AML. A minority of cases, displaying lymphoid-associated phenotypic markers and accompanying gene rearrangement, may represent a distinct subgroup of AML that arises from a rare, primitive stem cell, possessing extensive multilineage potential.
对10例表现出淋巴样相关标志物CD7和/或末端脱氧核苷酸转移酶（TdT）的成人急性髓系白血病（AML）患者进行了免疫球蛋白以及T细胞抗原受体β和γ基因重排的研究。6例TdT阳性病例中有2例存在克隆性重排的Ig基因，而8例CD7阳性AML中有6例，包括3例TdT阳性的病例，其免疫球蛋白以及T细胞受体β和γ基因均为种系构型。1例CD7阳性TdT阴性的AML病例所有3个基因均发生了克隆性重排。这些结果表明，在大多数成人AML病例中，TdT和/或CD7的表达并不伴有基因重排。少数表现出淋巴样相关表型标志物并伴有基因重排的病例，可能代表AML的一个独特亚组，其起源于一种罕见的、具有广泛多系分化潜能的原始干细胞。
