Hunter R L, Ferguson D J, Coppleson L W
Cancer. 1975 Aug;36(2):528-39. doi: 10.1002/1097-0142(197508)36:2<528::aid-cncr2820360232>3.0.co;2-u.
In a review of the histologic sections of axillary and internal mammary lymph nodes removed during surgery for invasive ductal carcinoma of the breast, we found that 16 of 17 patients in whom sinus histiocytosis was the dominant lymphoid proliferative reaction are alive with no evidence of cancer 5 or more years after operation. In contrast, 5 of 6 patients in whom germinal center hyperplasia was the only significant reaction found died of cancer in less than 5 years. Patients with both sinus histiocytosis and germinal center hyperplasia in significant amounts had survival that was intermediate; 17 of 25 of these patients are currently alive and apparently free of cancer. In addition, 5 of 6 patients in whom no evidence was found of any lymphoid proliferative reaction and 3 of 3 patients with diffuse cortical hyperplasia in their axillary lymph nodes died of cancer in less than 5 years. Germinal center hyperplasia was associated with nodal metastases anatomically in individual lymph nodes and statistically in the series of cases. The internal mammary lymph nodes of most cases showed less proliferative reaction to tumor than the axillary lymph nodes. The pattern of proliferative reactions in lymph nodes and its correlation with survival after surgery suggest that different immune reactions may either suppress or enhance the growth of carcinoma of the breast.
在对乳腺癌浸润性导管癌手术切除的腋窝和乳腺内淋巴结组织切片进行回顾时，我们发现，17例以窦组织细胞增生为主要淋巴样增殖反应的患者中，有16例在术后5年或更长时间存活且无癌症迹象。相比之下，6例仅发现生发中心增生为唯一显著反应的患者中有5例在不到5年的时间里死于癌症。窦组织细胞增生和大量生发中心增生的患者生存期处于中间水平；这些患者中有25例中的17例目前存活且显然无癌症。此外，6例未发现任何淋巴样增殖反应的患者中有5例，以及腋窝淋巴结有弥漫性皮质增生的3例患者均在不到5年的时间里死于癌症。生发中心增生在个体淋巴结的解剖结构上以及在这一系列病例的统计学上均与淋巴结转移相关。大多数病例的乳腺内淋巴结对肿瘤的增殖反应比腋窝淋巴结少。淋巴结中的增殖反应模式及其与术后生存的相关性表明，不同的免疫反应可能会抑制或促进乳腺癌的生长。
