Roeise O, Sivertsen S, Ruud T E, Bouma B N, Stadaas J O, Aasen A O
Department of Surgery, Ullevaal Hospital, University of Oslo, Norway.
Cancer. 1990 Mar 15;65(6):1355-9. doi: 10.1002/1097-0142(19900315)65:6<1355::aid-cncr2820650618>3.0.co;2-1.
The authors have studied components of the contact system in plasma obtained from patients with advanced gastrointestinal cancer. Plasma samples from 118 healthy blood donors served as controls. Plasma prekallikrein (PKK) values, evaluated by chromogenic peptide substrate technique, were significantly decreased in patients with cancer compared with healthy blood donors. High molecular weight kininogen (HMwK) and Hageman factor (FXII) values, assayed by immunochemical techniques, were also decreased in the patients with cancer. The changes of contact factors were most pronounced in patients with liver metastasis. The most striking observation in our study, however, was the elevated inhibitor values in patients with cancer. Alpha-2-macroglobulin (alpha 2-M) and C1 inhibitor (C1INH) values, determined both by functional and immunochemical techniques, were markedly increased in patients with cancer. In conclusion, this study shows that patients with intestinal cancer have reduced values of contact factors and markedly elevated inhibitor values which indicate that development of malignant tumors in the gastrointestinal tract is associated with changes in the contact system of plasma.
作者研究了晚期胃肠道癌患者血浆中接触系统的成分。来自118名健康献血者的血浆样本作为对照。通过发色肽底物技术评估的血浆前激肽释放酶（PKK）值，与健康献血者相比，癌症患者显著降低。通过免疫化学技术测定的高分子量激肽原（HMwK）和哈格曼因子（FXII）值在癌症患者中也降低。接触因子的变化在肝转移患者中最为明显。然而，我们研究中最显著的观察结果是癌症患者中抑制剂值升高。通过功能和免疫化学技术测定的α-2-巨球蛋白（α2-M）和C1抑制剂（C1INH）值在癌症患者中显著增加。总之，本研究表明，肠道癌患者接触因子值降低而抑制剂值显著升高，这表明胃肠道恶性肿瘤的发生与血浆接触系统的变化有关。
