Deutsch E, Dragosics B, Kopsa H, Mannhalter C, Rainer H
Thromb Res. 1983 Jul 15;31(2):351-64. doi: 10.1016/0049-3848(83)90336-5.
The behaviour of prekallikrein (PKK), factor XII, high molecular weight kininogen (HMWK) and kallikrein-inhibitor (KK-I) in 367 patients with various diseases is described. Malignancies lead to elevation of factor XII and KK-I, and reduction of PKK. The effect is more pronounced in patients with metastases. In renal diseases also one or more of the above mentioned parameters are abnormal. Defects requiring dialysis treatment significantly impair the contact factors. In this group low levels of PKK, Factor XII and HMWK and increased KK-I are common. In chronic renal disease patients, only F XII and KK-I are elevated, whereas PKK and HMWK are normal. Kidney transplantation leads to a rise in KK-I and reduction of PKK and HMWK. The values almost normalize few days after the operation. Factor XII, slightly increased immediately after transplantation, remains high in long term transplant recipients, whereas HMWK falls below normal. In liver disease patients, acute and chronic hepatitis, cirrhosis of the liver and coma, PKK is reduced. In cases with acute hepatitis PKK raises with recovery. Cirrhosis and coma lead to low HMWK and factor XII concentrations. KK-I is mostly affected during acute hepatitis, and is then highly increased. Our results clearly demonstrate that the biologic activity of one or more of contact factors is affected in many diseases.
本文描述了367例患有各种疾病的患者中前激肽释放酶（PKK）、因子Ⅻ、高分子量激肽原（HMWK）和激肽释放酶抑制剂（KK-I）的行为。恶性肿瘤会导致因子Ⅻ和KK-I升高，PKK降低。这种影响在有转移的患者中更为明显。在肾脏疾病中，上述参数中的一个或多个也会异常。需要透析治疗的缺陷会显著损害接触因子。在这组患者中，PKK、因子Ⅻ和HMWK水平较低以及KK-I升高很常见。在慢性肾病患者中，只有因子Ⅻ和KK-I升高，而PKK和HMWK正常。肾移植会导致KK-I升高，PKK和HMWK降低。术后几天这些值几乎恢复正常。因子Ⅻ在移植后立即略有升高，在长期移植受者中仍保持较高水平，而HMWK则降至正常以下。在肝病患者中，急性和慢性肝炎、肝硬化和昏迷患者，PKK降低。在急性肝炎患者中，PKK随着病情恢复而升高。肝硬化和昏迷会导致HMWK和因子Ⅻ浓度降低。KK-I在急性肝炎期间大多受到影响，然后会大幅升高。我们的结果清楚地表明，在许多疾病中，一种或多种接触因子的生物活性会受到影响。
