Morimatsu Yoshitaka, Akao Nobuaki, Akiyoshi Hiroya, Kawazu Taketoshi, Okabe Yoshinobu, Aizawa Hisamichi
Division of Respiratory Medicine, National Hospital Organization, Kumamoto Medical Center, Kumamoto, Japan.
Am J Trop Med Hyg. 2006 Aug;75(2):303-6.
We report a familial case of visceral larva migrans (VLM) caused by Toxocara canis larvae. Patient 1 was a 45-year-old man who presented to our university hospital complaining of mild fever, general fatigue, and headache. Patient 2 was a 71-year-old man and was the father of Patient 1; he presented complaining of cough and hyper-viscous white sputum. Laboratory data from both patients showed extensive eosinophilia, their chest X-ray findings revealed multiple pulmonary infiltrates, and their bronchoalveolar lavage fluid (BALF) showed an elevated eosinophil count. The diagnosis of VLM was made based on a positive result in a serological test using T. canis larval excretory-secretory both in the serum and BALF. T. canis larvae were identified in meat that was prepared from chicken taken from the same source as that ingested. This is the first report to identify antibodies in BALF in patients with VLM.
我们报告了一例由犬弓首蛔虫幼虫引起的内脏幼虫移行症（VLM）家族病例。患者1是一名45岁男性，因低热、全身乏力和头痛前来我院就诊。患者2是一名71岁男性，为患者1的父亲，因咳嗽和咳出黏稠白色痰液前来就诊。两位患者的实验室检查均显示嗜酸性粒细胞显著增多，胸部X线检查发现肺部有多处浸润，支气管肺泡灌洗液（BALF）中嗜酸性粒细胞计数升高。基于血清和BALF中犬弓首蛔虫幼虫排泄-分泌抗原的血清学检测呈阳性结果，确诊为VLM。在取自与摄入鸡肉相同来源的鸡肉制成的肉中发现了犬弓首蛔虫幼虫。这是首次报道在内脏幼虫移行症患者的支气管肺泡灌洗液中检测到抗体。
