Jayakar P, Chiappa K H
Clinical Neurophysiology Laboratory, Massachusetts General Hospital, Boston.
Electroencephalogr Clin Neurophysiol. 1990 Mar;75(3):251-4. doi: 10.1016/0013-4694(90)90178-m.
Reilly and Peters (1973) reported that photoparoxysmal responses (PPRs) that outlasted the stimulus correlated significantly with seizures as compared to self-limited PPRs. However, they defined a wide range of activity, including occipital spikes and slow wave bursts, as PPR. We examined EEGs of 3557 patients and 48 normal subjects for PPRs defined only as generalized spikes or spike-wave activity. None of the 48 normal subjects showed a PPR. PPRs were seen in 35 (1%) patients, 27 (77%) of these had a definite history of epilepsy, 3 (9%) had a questionable history, and 5 (14%) had had no seizures. PPRs were prolonged more than 100 msec beyond the stimulus in 11, and self-limited in 24. The incidence of seizures was not statistically different in these 2 groups. Furthermore, the classification of PPRs into these 2 groups could be influenced by the time at which the stimulus was stopped after the appearance of the PPR. PPRs are rare in normal subjects and non-epileptic patients and have a high correlation with seizures irrespective of their relationship to the strobe stimulus.
赖利和彼得斯（1973年）报告称，与自限性光阵发性反应（PPR）相比，持续时间超过刺激的光阵发性反应（PPR）与癫痫发作显著相关。然而，他们将包括枕叶尖波和慢波暴发在内的广泛活动定义为PPR。我们检查了3557例患者和48名正常受试者的脑电图，以寻找仅定义为全身性尖波或尖慢波活动的PPR。48名正常受试者均未出现PPR。35例（1%）患者出现了PPR，其中27例（77%）有明确的癫痫病史，3例（9%）有可疑病史，5例（14%）无癫痫发作史。11例患者的PPR在刺激后延长超过100毫秒，24例为自限性。这两组患者的癫痫发作发生率在统计学上无差异。此外，将PPR分为这两组可能会受到PPR出现后停止刺激时间的影响。PPR在正常受试者和非癫痫患者中很少见，并且与癫痫发作高度相关，无论其与频闪刺激的关系如何。
