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The NADPH- and iron-dependent lipid peroxidation in human placental microsomes.

作者信息

Milczarek Ryszard, Sokolowska Ewa, Hallmann Anna, Klimek Jerzy

机构信息

Department of Pharmaceutical Biochemistry, Medical University of Gdańsk, ul. Debinki 1, 80-211, Gdańsk, Poland.

出版信息

Mol Cell Biochem. 2007 Jan;295(1-2):105-11. doi: 10.1007/s11010-006-9279-3. Epub 2006 Aug 8.

DOI:10.1007/s11010-006-9279-3
PMID:16896536
Abstract

In pregnant females, placenta is the most important source of lipid hydroperoxides and other reactive oxygen species (ROS). The increased production of lipid peroxides is often linked to preeclampsia. In our study, we revealed that NADPH- and iron-dependent lipid peroxidation in human placental microsomes (HPM) occurred. In the presence of Fe2+ ion, HPM produced small amounts of thiobarbituric acid-reactive substances (TBARS) - a final product of lipid peroxidation. NADPH caused a strong increase of iron stimulated TBARS formation. TBARS formation was inhibited by superoxide dismutase, butylated hydroxytoluene and alpha-tocopherol but not by mannitol or catalase. TBARS and superoxide radical production was inhibited in similar manner by cytochrome P450 inhibitors. The results obtained led us to the following conclusions: (1) microsomal lipid peroxidation next to mitochondrial lipid peroxidation may by an important source of lipid hydroperoxides in blood during pregnancy and (2) superoxide radical released by microsomal cytochrome P450 is an important factor in NADPH- and iron-dependent lipid peroxidation in HPM.

摘要

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本文引用的文献

1
Progesterone synthesis by the human placenta.人胎盘的孕酮合成
Placenta. 2005 Apr;26(4):273-81. doi: 10.1016/j.placenta.2004.06.012.
2
Hypoxia-induced increase in soluble Flt-1 production correlates with enhanced oxidative stress in trophoblast cells from the human placenta.缺氧诱导可溶性Flt-1生成增加与人类胎盘滋养层细胞氧化应激增强相关。
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铁的不良表现：不适当的铁螯合是血管及其他进行性炎症和退行性疾病病因的主要促成因素。
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Lipid-soluble antioxidants and pregnancy: maternal serum levels of coenzyme Q10, alpha-tocopherol and gamma-tocopherol in preeclampsia and normal pregnancy.脂溶性抗氧化剂与妊娠：子痫前期和正常妊娠孕妇血清中辅酶Q10、α-生育酚和γ-生育酚的水平
Gynecol Obstet Invest. 2004;58(1):8-13. doi: 10.1159/000077011. Epub 2004 Feb 25.
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Eicosanoids in preeclampsia.子痫前期中的类二十烷酸
Prostaglandins Leukot Essent Fatty Acids. 2004 Feb;70(2):223-32. doi: 10.1016/j.plefa.2003.04.010.
9
Lipid and protein oxidation and antioxidant function in women with mild and severe preeclampsia.轻度和重度子痫前期女性的脂质与蛋白质氧化及抗氧化功能
Arch Gynecol Obstet. 2003 Apr;268(1):19-25. doi: 10.1007/s00404-002-0302-y. Epub 2002 Jul 6.
10
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Placenta. 2001 Apr;22(4):304-8. doi: 10.1053/plac.2001.0629.