尾加压素II对血管平滑肌细胞迁移的促进作用。
Enhancement of vascular smooth muscle cell migration by urotensin II.
作者信息
Matsusaka Satoshi, Wakabayashi Ichiro
机构信息
Department of Hygiene and Preventive Medicine, Yamagata University School of Medicine, Iida-Nishi 2-2-2, Yamagata 990-9585, Japan.
出版信息
Naunyn Schmiedebergs Arch Pharmacol. 2006 Aug;373(5):381-6. doi: 10.1007/s00210-006-0086-x. Epub 2006 Aug 1.
The effects of urotensin II (UII) on migration of human aortic smooth muscle cells (HASMCs) were investigated. UII (1-100 nM) significantly increased velocity of HASMC motility in a concentration-dependent manner. Stress-fiber formation and ERK (p44/p42) activity were also increased by UII. U0126 and PD 98059, MEK inhibitors, abolished the effects of UII on motility velocity and stress-fiber formation. These results suggest that UII enhances HASMC migration through activation of an ERK-dependent pathway.
研究了尾加压素II（UII）对人主动脉平滑肌细胞（HASMCs）迁移的影响。UII（1 - 100 nM）以浓度依赖的方式显著提高了HASMCs的运动速度。UII还增加了应力纤维形成和ERK（p44/p42）活性。MEK抑制剂U0126和PD 98059消除了UII对运动速度和应力纤维形成的影响。这些结果表明，UII通过激活ERK依赖的途径增强了HASMCs的迁移。
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