新诊断的胰岛素依赖型糖尿病（IDDM）患者中CD5 + B淋巴细胞百分比增加。

Enhanced percentage of CD5+ B lymphocytes in newly diagnosed IDDM patients.

作者信息

Nicoletti F, Meroni P L, Barcellini W, Steinsväg P O, Di Mauro M, Lunetta M, Pagano M, Consoli U, Zanussi C

机构信息

Institute of Internal Medicine, Infectious Diseases and Immunopathology, University of Milan, Italy.

出版信息

Immunol Lett. 1990 Jan;23(3):211-5. doi: 10.1016/0165-2478(90)90194-u.

DOI:10.1016/0165-2478(90)90194-u

PMID:1689697

Abstract

The percentage of CD5+ B lymphocytes, the prevalence of islet cell antibodies (ICA) and of anti-insulin autoantibodies (IAA) and HLA-A-B-C and DR antigens were studied in 32 newly diagnosed insulin-dependent diabetes mellitus (IDDM) patients, in 12 non-insulin-dependent diabetes mellitus (NIDDM) patients and in 12 healthy subjects. The percentage of CD5+ B lymphocytes ranged from 18% to 51.2% (mean 40.3 +/- 11%) in IDDM patients, whereas in NIDDM patients and in controls it ranged from 20% to 25.2%, (mean 21.3 +/- 4.1%) and from 16% to 24%, (mean 19.3 +/- 1.9%), respectively (P less than 0.01 vs. NIDDM patients and vs. controls). There was no correlation between a higher percentage of CD5+ B lymphocytes and the presence of ICA and/or IAA, and their titres, and/or of any HLA-A-B-C and DR antigens. Thus, an enhanced percentage of CD5+ B lymphocytes may be present in newly diagnosed IDDM patients; the possible role of this cell type in the pathogenesis of IDDM needs further investigation.

摘要

对32例新诊断的胰岛素依赖型糖尿病（IDDM）患者、12例非胰岛素依赖型糖尿病（NIDDM）患者和12名健康受试者，研究了CD5 + B淋巴细胞百分比、胰岛细胞抗体（ICA）和抗胰岛素自身抗体（IAA）的患病率以及HLA - A - B - C和DR抗原。IDDM患者中CD5 + B淋巴细胞百分比在18%至51.2%之间（平均40.3±11%），而NIDDM患者和对照组中该百分比分别在20%至25.2%之间（平均21.3±4.1%）和16%至24%之间（平均19.3±1.9%）（与NIDDM患者和对照组相比，P < 0.01）。CD5 + B淋巴细胞百分比升高与ICA和/或IAA的存在及其滴度以及任何HLA - A - B - C和DR抗原之间均无相关性。因此，新诊断的IDDM患者中可能存在CD5 + B淋巴细胞百分比升高的情况；这种细胞类型在IDDM发病机制中的可能作用需要进一步研究。