Lee Shin-Seok, Yoon Hyun-Jung, Park Yong-Wook
Department of Rheumatology, Chonnam National University Medical School, Gwangju, 501-746, South Korea.
Rheumatol Int. 2006 Nov;27(1):73-7. doi: 10.1007/s00296-006-0174-8. Epub 2006 Aug 5.
To examine the levels of antipolymer antibody (APA) in Korean female patients with fibromyalgia (FM) and to determine whether the levels of APA correlate with FM severity. Serum samples from patients with FM (n = 69), patients with rheumatoid arthritis (RA) (n = 71), and controls (n = 75) were assayed for APA. All of the subjects were female, and the controls were age-matched healthy volunteers. FM tender point counts and scores were examined, and FM patients were asked to complete a Korean version of the Fibromyalgia Impact Questionnaire (FIQ), the State-Trait Anxiety Inventory (STAI), and the Beck Depression Inventory (BDI). APA-positive samples were detected in five (7.2%) of the 69 FM patients, seven (9.9%) of the 71 RA patients, and four (5.3%) of the 75 controls. The prevalence of seropositivity and the level of APA in FM patients did not differ from those in RA patients and controls. The proportion positive for APA was not higher for FM patients with severe symptoms than for FM patients with mild symptoms. There was a negative association between the APA level and age. The APA level in FM patients was not correlated with age at diagnosis, age at symptom onset, disease duration, education, tender point counts and scores, FIQ, STAI, or BDI. The prevalence of APA in Korean FM patients was quite low. Owing to the low prevalence of APA in this study, the APA assay did not distinguish FM patients with severe symptoms from those with mild symptoms.
检测韩国女性纤维肌痛（FM）患者的抗聚合物抗体（APA）水平，并确定APA水平是否与FM严重程度相关。对FM患者（n = 69）、类风湿性关节炎（RA）患者（n = 71）和对照组（n = 75）的血清样本进行APA检测。所有受试者均为女性，对照组为年龄匹配的健康志愿者。检查FM压痛点计数和评分，并要求FM患者完成韩国版纤维肌痛影响问卷（FIQ）、状态-特质焦虑量表（STAI）和贝克抑郁量表（BDI）。69例FM患者中有5例（7.2%）、71例RA患者中有7例（9.9%）、75例对照组中有4例（5.3%）检测到APA阳性样本。FM患者的血清阳性率和APA水平与RA患者及对照组无差异。症状严重的FM患者APA阳性比例并不高于症状较轻的FM患者。APA水平与年龄呈负相关。FM患者的APA水平与诊断年龄、症状出现年龄、病程、教育程度、压痛点计数和评分、FIQ、STAI或BDI均无相关性。韩国FM患者中APA的患病率相当低。由于本研究中APA患病率较低，APA检测无法区分症状严重的FM患者和症状较轻的FM患者。
