Saburkina Inga, Pauza Dainius H
Institute for Anatomy, Kaunas University of Medicine, A. Mickeviciaus Street 9, Kaunas 44307, Lithuania.
Anat Embryol (Berl). 2006 Nov;211(6):585-94. doi: 10.1007/s00429-006-0110-4. Epub 2006 Aug 2.
The aim of the study was to determine the morphology of epicardiac ganglia in human fetuses at different stages of their development as these ganglia are considered to be of a pivotal clinical importance. Twenty-one fetal hearts were investigated applying a technique of histochemistry for acetylcholinesterase to visualize the epicardiac neural ganglionated plexus with its subsequent stereoscopic examination on total organs. In all of the examined fetuses, epicardiac neural plexus with numerous ganglia was well recognizable and could be clearly differentiated into seven ganglionated subplexuses, topography and structural organization of which were typical for hearts of adult human. The largest ganglion number comprising 77% of all counted ganglia was identified on the dorsal atrial surface. Fetal epicardiac plexus in gestation period of 15-40 weeks contained 929 +/- 62 ganglia, but ganglion amount did vary substantially from heart to heart. In conclusion, this study implies that the human fetal epicardiac ganglia occupy their definitive location already at gestation period from 15 weeks and their number as well as distribution on heart surface presumably is not age dependent.
本研究的目的是确定人类胎儿不同发育阶段的心外膜神经节的形态，因为这些神经节被认为具有关键的临床重要性。应用乙酰胆碱酯酶组织化学技术对21个胎儿心脏进行研究，以可视化心外膜神经节丛，并随后对整个器官进行立体检查。在所有检查的胎儿中，具有众多神经节的心外膜神经丛清晰可见，可明确分为七个神经节亚丛，其拓扑结构和组织结构与成人心脏典型特征一致。在心房背侧表面发现了数量最多的神经节，占所有计数神经节的77%。妊娠15 - 40周的胎儿心外膜丛包含929±62个神经节，但神经节数量在不同心脏之间差异很大。总之，本研究表明，人类胎儿的心外膜神经节在妊娠15周时就已占据其最终位置，其数量以及在心脏表面的分布可能与年龄无关。
