Hillemacher T, Frieling H, Bayerlein K, Wilhelm J, Kornhuber J, Bleich S
Department of Psychiatry and Psychotherapy, University of Erlangen-Nuremberg, Erlangen, Germany.
J Neural Transm (Vienna). 2007 Feb;114(2):151-4. doi: 10.1007/s00702-006-0541-3. Epub 2006 Aug 10.
Recent studies have shown that both, elevated homocysteine and prolactin plasma levels are associated with a higher risk of alcohol withdrawal seizures. The aim of this study was to evaluate the predictive qualities of a combined assessment of homocysteine and prolactin for previous alcohol withdrawal seizures. Therefore, 117 male patients suffering from alcohol dependency were included into the study. Homocysteine was measured directly at admission, prolactin the morning following admission for detoxification treatment. Pearson's chi(2)-test showed significant results for the combined assessment of both parameters (chi(2) = 14.71, p = 0.001). Multivariate logistic regression also revealed significant predictive qualities (p = 0.001, OR = 9.23, 95%CI = 2.36-36.05). A combination of both, homocysteine and prolactin, may help to assess the individual risk of alcohol withdrawal seizures in clinical practice.
近期研究表明，血浆同型半胱氨酸水平升高和催乳素水平升高均与酒精戒断性癫痫发作风险较高相关。本研究的目的是评估同型半胱氨酸和催乳素联合评估对既往酒精戒断性癫痫发作的预测价值。因此，117名酒精依赖男性患者被纳入研究。入院时直接测定同型半胱氨酸，入院接受解毒治疗后的早晨测定催乳素。Pearson卡方检验显示，对这两个参数进行联合评估有显著结果（卡方 = 14.71，p = 0.001）。多因素逻辑回归也显示出显著的预测价值（p = 0.001，比值比 = 9.23，95%置信区间 = 2.36 - 36.05）。同型半胱氨酸和催乳素两者结合，可能有助于在临床实践中评估个体酒精戒断性癫痫发作的风险。
