Fiessinger J N, Schäfer M
Service de Pathologie Vasculaire, Hôpital Broussais, Paris, France.
Lancet. 1990 Mar 10;335(8689):555-7. doi: 10.1016/0140-6736(90)90346-7.
152 patients with thromboangiitis obliterans (Buerger's disease) and pain from critical leg ischaemia were randomly allocated to receive iloprost, a chemically stable prostacyclin analogue, or low-dose aspirin, for 28 days in a double-blind trial. On review, 19 patients did not fulfil the stringent entry criteria. Of the other 133 patients, 98 also had leg ulcers. After 21-28 days, 58 (85%) of 68 iloprost-treated patients showed ulcer healing or relief of ischaemic pain, compared with 11 (17%) of 65 in the aspirin-treated group. 43 (63%) on iloprost treatment had complete relief of pain, compared with 18 (28%) on aspirin. Ulcers healed completely in 18 of 52 (35%) who received iloprost compared with 6 of 46 (13%) who received aspirin. 6 months after the start of treatment, the response rate was 45 of 51 (88%) patients treated with iloprost compared with 12 of 44 (21%) patients treated with aspirin.
152例血栓闭塞性脉管炎（伯格氏病）且因严重下肢缺血而疼痛的患者被随机分配接受伊洛前列素（一种化学性质稳定的前列环素类似物）或小剂量阿司匹林治疗，进行为期28天的双盲试验。复查时，19例患者不符合严格的入选标准。在其余133例患者中，98例还患有腿部溃疡。21至28天后，68例接受伊洛前列素治疗的患者中有58例（85%）溃疡愈合或缺血性疼痛缓解，相比之下，阿司匹林治疗组65例患者中有11例（17%）。接受伊洛前列素治疗的43例（63%）患者疼痛完全缓解，相比之下，阿司匹林治疗组为18例（28%）。接受伊洛前列素治疗的52例患者中有18例（35%）溃疡完全愈合，相比之下，接受阿司匹林治疗的46例患者中有6例（13%）。治疗开始6个月后，接受伊洛前列素治疗的51例患者中有45例（88%）有反应，相比之下，接受阿司匹林治疗的44例患者中有12例（21%）。
