[肾病患儿中的胎球蛋白A]

[Fetuin A in children with renal diseases].

作者信息

Ziółkowska Helena, Wojnar Julita, Pańczyk-Tomaszewska Małgorzata, Roszkowska-Blaim Maria

机构信息

Katedra i Klinika Pediatrii i Nefrologii, Akademii Medycznej w Warszawie.

出版信息

Przegl Lek. 2006;63 Suppl 3:54-6.

PMID:16898488

Abstract

UNLABELLED

Fetuin A, 59 kDa protein, produced in the liver is a circulating inhibitor of vascular calcification. The aim of the study was to estimate a concentration of fetuin A in children with renal diseases. Fifty three children were examined: 18 with idiopathic nephrotic syndrome (NS) aged 2.5 to 14.5 years, mean 6.6 +/- 3.6 and 35 with chronic renal failure (CRF) aged 4.5 to 20 years, mean 13.3 +/- 3.9. The control group (K) consisted of 22 healthy children, aged from 6.5 to 17.5 years, mean 10.8 +/- 3.3. In all children serum concentration of fetuin A (ELISA method, BioVendor), calcium (sCa), phosphorus (sP), protein (P), albumin (Alb), total cholesterol (TC) and triglycerides (TG) were measured. The daily protein excretion in children with proteinuria (mg/kg/day) and the serum parathormone (PTH) level in children with CRF were analysed.

RESULTS

The concentration of fetuin A was the lowest in children with NS (78.1 +/- 24.5 ng/ml) and was statistically different (p=0.0003) than in group K (101.4 +/- 11 ng/ml) and group CRF (106.7 +/- 13.7 ng/ml). In group NS significant correlations were found between concentrations of fetuin A and sCa (r=0.62, p<0.01), P (r=0.59, p= 0.01) and Alb (r=0.64, p<0.01) and negative correlations with concentration of TC (r=-0.68, p<0.01) and daily proteinuria (r=-0.79, p<0.001). In groups K and CRF the correlations of fetuin A level and analysed parameters were not found.

CONCLUSION

Low concentration of fetuin A in children with nephrotic syndrome may be the additional agent to promote the atherogenic lesions.

摘要

未标注

胎球蛋白A是一种在肝脏中产生的59 kDa蛋白质，是血管钙化的循环抑制剂。本研究的目的是评估肾病患儿胎球蛋白A的浓度。对53名儿童进行了检查：18名患有特发性肾病综合征（NS），年龄在2.5至14.5岁之间，平均年龄为6.6±3.6岁；35名患有慢性肾衰竭（CRF），年龄在4.5至20岁之间，平均年龄为13.3±3.9岁。对照组（K）由22名健康儿童组成，年龄在6.5至17.5岁之间，平均年龄为10.8±3.3岁。检测了所有儿童血清中的胎球蛋白A（ELISA法，BioVendor公司）、钙（sCa）、磷（sP）、蛋白质（P）、白蛋白（Alb）、总胆固醇（TC）和甘油三酯（TG）。分析了蛋白尿患儿的每日蛋白排泄量（mg/kg/天）以及CRF患儿的血清甲状旁腺激素（PTH）水平。

结果

NS患儿的胎球蛋白A浓度最低（78.1±24.5 ng/ml），与K组（101.4±11 ng/ml）和CRF组（106.7±13.7 ng/ml）相比，差异有统计学意义（p = 0.0003）。在NS组中，发现胎球蛋白A浓度与sCa（r = 0.62，p < 0.01）、P（r = 0.59，p = 0.01）和Alb（r = 0.64，p < 0.01）之间存在显著相关性，与TC浓度（r = -0.68，p < 0.01）和每日蛋白尿（r = -0.79，p < 0.001）呈负相关。在K组和CRF组中，未发现胎球蛋白A水平与分析参数之间的相关性。