[肾病综合征患儿的胎球蛋白A]

[Fetuin A in children with nephrotic syndrome].

作者信息

Pańczyk-Tomaszewska Małgorzata, Skrzypczyk Piotr, Ziółkowska Helena, Adamczuk Dominika, Roszkowska-Blaim Maria

机构信息

Katedra i Klinika Pediatrii i Nefrologii, Warszawski Uniwersytet Medyczny.

出版信息

Pol Merkur Lekarski. 2008;24 Suppl 4:65-7.

PMID:18924506

Abstract

AIM OF THE STUDY

To estimate concentration of fetuin A in children with nephrotic syndrome (NS).

MATERIAL AND METHODS

53 children with NS aged from 2.5 to 17.2 years (mean age 7.7 +/- 4.4 years), 27 in remission of NS, 26 in relapse of NS were involved into the study. The control group consisted of 22 healthy children, aged from 6.5 to 17.5 years, mean age 10.8 +/- 3.3 years. In all children serum concentration of fetuin A, calcium, phosphorus, total cholesterol, albumin, triglycerides, and total daily urine protein loss were measured.

RESULTS

The concentration of fetuin A in children in relapse was significantly lower compared to children in remission and control group (65.9 +/- 28; 87.2 +/- 23.2; 101.9 +/- 11.6 ng/mL, respectively, p < 0.0001). Significant correlation was found between concentrations of fetuin A and albumin level (r = 0.36, p < 0.05) and calcium concentration (r = 0.30, p < 0.05) and negative correlation between concentration of fetuin A and daily proteinuria (r = -0.36, p < 0.05).

CONCLUSION

Low concentration of fetuin A in children in relapse of NS it may depends on proteinuria.

摘要

研究目的

评估肾病综合征（NS）患儿血清胎球蛋白A的浓度。

材料与方法

纳入53例年龄在2.5至17.2岁（平均年龄7.7±4.4岁）的NS患儿，其中27例处于NS缓解期，26例处于NS复发期。对照组由22例年龄在6.5至17.5岁（平均年龄10.8±3.3岁）的健康儿童组成。检测所有儿童血清中胎球蛋白A、钙、磷、总胆固醇、白蛋白、甘油三酯的浓度以及每日尿蛋白总丢失量。

结果

复发期患儿的胎球蛋白A浓度显著低于缓解期患儿及对照组（分别为65.9±28、87.2±23.2、101.9±11.6 ng/mL，p<0.0001）。胎球蛋白A浓度与白蛋白水平（r=0.36，p<0.05）和钙浓度（r=0.30，p<0.05）之间存在显著相关性，而胎球蛋白A浓度与每日蛋白尿之间存在负相关性（r=-0.36，p<0.05）。