Qu Zhilin, Weiss James N
Department of Medicine (Cardiology), David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA.
J Cardiovasc Electrophysiol. 2006 Sep;17(9):1042-9. doi: 10.1111/j.1540-8167.2006.00567.x. Epub 2006 Aug 1.
Cardiac arrhythmias, characterized by single or multiple reentrant circuits, represent a dynamic phenomenon in an excitable medium. In this review, we provide a brief overview of how cardiac action potential duration restitution, conduction velocity restitution, and intracellular calcium cycling regulate the dynamics of action potential excitation and wave propagation in relation to the genesis and maintenance of cardiac arrhythmias.
以单个或多个折返环为特征的心律失常是可兴奋介质中的一种动态现象。在本综述中,我们简要概述了心脏动作电位时程恢复、传导速度恢复和细胞内钙循环如何调节动作电位兴奋和波传播的动力学,以及它们与心律失常的发生和维持的关系。