心脏心律失常的发生和维持中的混沌。
Chaos in the genesis and maintenance of cardiac arrhythmias.
机构信息
Department of Medicine (Cardiology), David Geffen School of Medicine at University of California, 650 Charles E. Young Drive South, Los Angeles, CA 90095, USA.
出版信息
Prog Biophys Mol Biol. 2011 May;105(3):247-57. doi: 10.1016/j.pbiomolbio.2010.11.001. Epub 2010 Nov 13.
Abstract
Dynamical chaos, an irregular behavior of deterministic systems, has been widely shown in nature. It also has been demonstrated in cardiac myocytes in many studies, including rapid pacing-induced irregular beat-to-beat action potential alterations and slow pacing-induced irregular early afterdepolarizations, etc. Here we review the roles of chaos in the genesis of cardiac arrhythmias, the transition to ventricular fibrillation, and the spontaneous termination of fibrillation, based on evidence from computer simulation of mathematical models and experiments of animal models.
摘要
动力混沌，一种确定性系统的不规则行为，在自然界中得到了广泛的展示。在许多研究中，包括快速起搏诱导的不规则心搏到心搏动作电位改变和缓慢起搏诱导的不规则早期后除极等，也已经证明了这种混沌在心律失常的发生、向心室颤动的转变以及颤动的自发终止中的作用。本综述基于数学模型的计算机模拟和动物模型的实验证据，对混沌在心律失常发生、向心室颤动转变以及颤动的自发终止中的作用进行了回顾。
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