Stamatoyannopoulos G, Veith R, al-Khatti A, Papayannopoulou T
Department of Medicine, University of Washington, Seattle 98195.
Am J Pediatr Hematol Oncol. 1990 Spring;12(1):21-6. doi: 10.1097/00043426-199021000-00005.
During the last several years, studies in humans and experimental animals have identified several compounds that induce fetal hemoglobin in the adult. These include: cell-cycle-specific drugs, other cytotoxic drugs, butyric acid analogs, and erythropoietin. Several of these compounds induce fetal hemoglobin indirectly by triggering kinetics of rapid erythroid regeneration. High doses of erythropoietin increase the frequency of erythroid progenitors programmed to hemoglobin F. This results in transient increases of hemoglobin F-containing cells (F cells) in the peripheral blood. Erythropoietin and hydroxyurea increase F cells in a cooperative fashion. Although high doses of erythropoietin can induce F cell production in humans, the practical relevance of such observations is unclear
在过去几年中，针对人类和实验动物的研究已经鉴定出几种可在成体中诱导胎儿血红蛋白产生的化合物。这些化合物包括：细胞周期特异性药物、其他细胞毒性药物、丁酸类似物以及促红细胞生成素。其中几种化合物通过触发快速红系再生的动力学间接诱导胎儿血红蛋白。高剂量的促红细胞生成素会增加定向生成血红蛋白F的红系祖细胞的频率。这导致外周血中含血红蛋白F的细胞（F细胞）短暂增加。促红细胞生成素和羟基脲以协同方式增加F细胞。尽管高剂量的促红细胞生成素可在人类中诱导F细胞产生，但此类观察结果的实际相关性尚不清楚
