Al-Khatti A, Papayannopoulou T, Knitter G, Fritsch E F, Stamatoyannopoulos G
Department of Medicine, University of Washington, Seattle 98195.
Blood. 1988 Aug;72(2):817-9.
Chronically anemic baboons on a continuous hydroxyurea regimen were treated with pulsed doses of recombinant human erythropoietin (rHuEpo) to test whether the combination of these two compounds, which individually induce F-cell production, can enhance further F-cell output. A low-F-cell-responding animal under chronic hydroxyurea treatment was given three separate pulses of Epo and responded with F-reticulocyte increments that were similar to the sum increments caused by either hydroxyurea alone or rHuEpo alone. The same results were obtained in a high-F-responding animal similarly treated. These findings suggest that rHuEpo and hydroxyurea can increase F cell numbers in an additive fashion. It is speculated that both compounds act through perturbation of erythroid differentiation kinetics.
对长期接受羟基脲治疗的慢性贫血狒狒给予脉冲剂量的重组人促红细胞生成素（rHuEpo），以测试这两种单独诱导F细胞生成的化合物联合使用是否能进一步提高F细胞产量。对一只在慢性羟基脲治疗下F细胞反应较低的动物给予三次单独的促红细胞生成素脉冲，其F网织红细胞增加情况与单独使用羟基脲或单独使用rHuEpo所引起的增加总和相似。对一只F反应较高的动物进行类似治疗也得到了相同结果。这些发现表明，rHuEpo和羟基脲可以以相加的方式增加F细胞数量。据推测，这两种化合物都是通过干扰红系分化动力学起作用的。
