Martinez-Rodriguez J E, Munteis E, Roquer J
Department of Neurology, Hospital del Mar, Institut Municipal d'Assistència Sanitaria, Institut Municipal d'Investigació Médica, Universitat Autònoma de Barcelona, Barcelona, Spain.
Mult Scler. 2006 Aug;12(4):515-7. doi: 10.1191/135248506ms1321cr.
Disturbances of the central thermoregulation in patients with multiple sclerosis (MS) are not often reported. We describe a 45-year old patient with a 13-year history of MS, who developed a clinical picture of recurrent hyperthermia. MRI showed a bilateral involvement of the hypothalamus in the setting of diffuse white matter disease. Serial body temperature measurement for five consecutive months disclosed an inversion of the circadian temperature rhythm. The clinical presentation and MRI findings suggested abnormalities of the central thermal control in relation to MS widespread involvement of the central nervous system (CNS).
多发性硬化症（MS）患者中枢体温调节紊乱的情况并不常被报道。我们描述了一名45岁、有13年MS病史的患者，该患者出现了反复高热的临床表现。MRI显示在弥漫性白质疾病背景下双侧下丘脑受累。连续五个月的体温测量显示昼夜体温节律倒置。临床表现和MRI结果提示，由于MS广泛累及中枢神经系统（CNS），导致中枢热调节异常。
