自主神经功能障碍、免疫调节与多发性硬化症。
Autonomic dysfunction, immune regulation, and multiple sclerosis.
机构信息
Department of Clinical Neurological Sciences, London Health Sciences Centre, Western University, London, ON, Canada.
出版信息
Clin Auton Res. 2016 Feb;26(1):23-31. doi: 10.1007/s10286-015-0325-7. Epub 2015 Dec 21.
OBJECTIVE
To review existing evidence regarding interactions between the autonomic nervous system and the immune system functions in multiple sclerosis.
METHODS
We reviewed the literature regarding new insights linking autonomic dysfunction to immune deregulation in multiple sclerosis, with particular focus on the specific influence of sympathetic and parasympathetic dysfunction on inflammatory and neurodegenerative processes.
RESULTS
Autonomic dysfunction is common in multiple sclerosis, representing a significant cause of disability. Several connections between pathologic immune pathways and the autonomic nervous system function were found.
CONCLUSIONS
Autonomic dysfunction may enhance inflammatory and neurodegenerative pathways that are of major importance in multiple sclerosis. Autonomic dysfunction can present with highly variable manifestations. Sympathetic and parasympathetic dysfunction displays different patterns in multiple sclerosis, with specific impact on inflammation and neurodegeneration.
目的
综述自主神经系统与免疫系统功能在多发性硬化中的相互作用的现有证据。
方法
我们综述了有关自主功能障碍与多发性硬化中免疫失调相关的新见解的文献，特别关注交感和副交感功能障碍对炎症和神经退行性过程的具体影响。
结果
自主功能障碍在多发性硬化中很常见，是导致残疾的重要原因。已经发现病理性免疫途径与自主神经系统功能之间存在多种联系。
结论
自主功能障碍可能增强在多发性硬化中具有重要意义的炎症和神经退行性途径。自主功能障碍的表现可能有很大差异。交感和副交感功能障碍在多发性硬化中表现出不同的模式，对炎症和神经退行性变有特定影响。
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