Kaboudin Babak, Haghighat Hamideh, Yokomatsu Tsutomu
Department of Chemistry, Institute for Advanced Studies in Basic Sciences, Gava Zang, Zanjan 45195-1159, Iran.
J Org Chem. 2006 Aug 18;71(17):6604-6. doi: 10.1021/jo060547h.
The reaction of aromatic and aliphatic aldehydes with hypophosphorus acid under microwave irradiation was examined. The reaction gave a mixture of a racemic pair of bis(alpha-hydroxyalkyl)phosphinic acids and acetal derivatives from the corresponding bis(alpha-hydroxyalkyl)phosphinic acids of meso-stereochemistry in good yield. The difference in solubility in organic solvents due to polarity allowed us to readily separate these compounds. This method constitutes an easy, rapid, and good-yielding preparation and separation of bis(alpha-hydroxyalkyl) phosphinic acid diastereoisomers from simple starting materials using microwave irradiation.
研究了芳香醛和脂肪醛在微波辐射下与次磷酸的反应。该反应得到了一对外消旋的双（α-羟烷基）次膦酸混合物以及来自相应内消旋立体化学的双（α-羟烷基）次膦酸的缩醛衍生物，产率良好。由于极性导致在有机溶剂中的溶解度差异，使我们能够轻松分离这些化合物。该方法构成了一种使用微波辐射从简单起始原料中简便、快速且高产率地制备和分离双（α-羟烷基）次膦酸非对映异构体的方法。
