通过α-溴乙酸酯、丙二腈和芳香醛的多组分环化一步合成多取代苯衍生物。
One-step synthesis of polysubstituted benzene derivatives by multi-component cyclization of alpha-bromoacetate, malononitrile and aromatic aldehydes.
作者信息
Yan Chao Guo, Song Xiao Kai, Wang Qi Fang, Sun Jing, Siemeling Ulrich, Bruhn Clemens
机构信息
College of Chemistry & Chemical Engineering Yangzhou University, Yangzhou 225002, China.
出版信息
Chem Commun (Camb). 2008 Mar 28(12):1440-2. doi: 10.1039/b718171j. Epub 2008 Jan 25.
DOI:10.1039/b718171j
PMID:18338049
Abstract
Polysubstituted benzene derivatives with an unprecedented substitution pattern are produced in a novel one-pot multi-component cyclization reaction from pyridine, ethyl alpha-bromoacetate, malononitrile and aromatic aldehyde in refluxing acetonitrile.
摘要
具有前所未有的取代模式的多取代苯衍生物，是通过吡啶、α-溴乙酸乙酯、丙二腈和芳香醛在回流乙腈中进行新颖的一锅多组分环化反应制备而成的。
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