Forner Lone, Nielsen Claus Henrik, Bendtzen Klaus, Larsen Tove, Holmstrup Palle
Noerre Allé 20, Copenhagen N 2200, Denmark.
J Clin Periodontol. 2006 Oct;33(10):724-9. doi: 10.1111/j.1600-051X.2006.00964.x. Epub 2006 Aug 10.
Bacteremia frequently occurs after dental treatment. Periodontal inflammation may influence the incidence, magnitude and duration of bacteremia. The presence of circulating oral bacteria or bacterial components may induce cytokine synthesis in blood cells, which may contribute to the development or exacerbation of atherosclerosis. The present study tested the hypothesis that bacteremia occurring after scaling in periodontitis patients results in altered plasma levels of cytokines. Twenty periodontitis patients were subjected to scaling. Blood samples at baseline and at 0.5, 10 and 30 minutes postscaling were examined for bacteremia whereas baseline and eight-hour postscaling blood samples were examined for the levels of IL-1beta, TNF-alpha, IL-6, IL-8, IL-10 and IL-12p70. IL-6 levels were significantly increased eight hours after scaling, while IL-8 was significantly decreased. No systematic changes occurred in the levels of IL-1beta, TNF-alpha, IL-10 and IL-2p70. IL-6 levels may be increased while IL-8 may be decreased due to scaling, which may have implications for general health.
菌血症常在牙科治疗后发生。牙周炎症可能会影响菌血症的发生率、严重程度和持续时间。循环中的口腔细菌或细菌成分的存在可能会诱导血细胞中细胞因子的合成，这可能会促进动脉粥样硬化的发展或加重。本研究检验了这样一个假设，即牙周炎患者洗牙后发生的菌血症会导致血浆中细胞因子水平的改变。20名牙周炎患者接受了洗牙治疗。检测洗牙前以及洗牙后0.5分钟、10分钟和30分钟的血样以检查是否存在菌血症，同时检测洗牙前以及洗牙后8小时血样中白细胞介素-1β（IL-1β）、肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）、白细胞介素-8（IL-8）、白细胞介素-10（IL-10）和白细胞介素-12p70的水平。洗牙后8小时，IL-6水平显著升高，而IL-8水平显著降低。IL-1β、TNF-α、IL-10和IL-2p70的水平没有发生系统性变化。洗牙可能会使IL-6水平升高而使IL-8水平降低，这可能会对整体健康产生影响。
