State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, National Clinical Research Center for Oral Diseases, Sichuan University, Chengdu, China.
Department of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Int J Oral Sci. 2022 Mar 2;14(1):14. doi: 10.1038/s41368-022-00163-7.
Oral bacteria directly affect the disease status of dental caries and periodontal diseases. The dynamic oral microbiota cooperates with the host to reflect the information and status of immunity and metabolism through two-way communication along the oral cavity and the systemic organs. The oral cavity is one of the most important interaction windows between the human body and the environment. The microenvironment at different sites in the oral cavity has different microbial compositions and is regulated by complex signaling, hosts, and external environmental factors. These processes may affect or reflect human health because certain health states seem to be related to the composition of oral bacteria, and the destruction of the microbial community is related to systemic diseases. In this review, we discussed emerging and exciting evidence of complex and important connections between the oral microbes and multiple human systemic diseases, and the possible contribution of the oral microorganisms to systemic diseases. This review aims to enhance the interest to oral microbes on the whole human body, and also improve clinician's understanding of the role of oral microbes in systemic diseases. Microbial research in dentistry potentially enhances our knowledge of the pathogenic mechanisms of oral diseases, and at the same time, continuous advances in this frontier field may lead to a tangible impact on human health.
口腔细菌直接影响龋齿和牙周病的疾病状况。动态口腔微生物群通过口腔和全身器官的双向通讯与宿主合作，反映免疫和代谢的信息和状态。口腔是人体与环境之间最重要的相互作用窗口之一。口腔内不同部位的微环境具有不同的微生物组成，并受到复杂信号、宿主和外部环境因素的调节。这些过程可能会影响或反映人体健康，因为某些健康状况似乎与口腔细菌的组成有关，而微生物群落的破坏与系统性疾病有关。在这篇综述中，我们讨论了口腔微生物与多种人类系统性疾病之间复杂而重要的联系的新出现的令人兴奋的证据，以及口腔微生物对系统性疾病的可能贡献。本综述旨在提高人们对整个人体口腔微生物的兴趣，同时提高临床医生对口腔微生物在系统性疾病中的作用的认识。牙科领域的微生物研究有可能增强我们对口腔疾病发病机制的认识，同时，这一前沿领域的持续进展可能会对人类健康产生切实的影响。
