Progesterone binding to the tryptophan residues of human alpha1-acid glycoprotein.
作者信息
Albani J R
机构信息
Laboratoire de Biophysique Moléculaire, Université des Sciences et Technologies de Lille, Bât. C6. 59655 Villeneuve d'Ascq Cédex, France.
出版信息
Carbohydr Res. 2006 Nov 6;341(15):2557-64. doi: 10.1016/j.carres.2006.07.012. Epub 2006 Aug 8.
PMID:16901474
Abstract
Binding studies between progesterone and alpha1-acid glycoprotein allowed us to demonstrate that the binding site of progesterone contains one hydrophobic tryptophan residue and that the structure of the protein is not altered upon binding. The data obtained at saturated concentrations of progesterone clearly reveal the type of interaction at physiological levels.
摘要
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