Cortina P, Garrido J A, Tomas J F, Unamuno P, Armijo M
Departamento de Dermatologia, Hospital General Universitario, Salamanca, España.
Dermatologica. 1990;180(2):106-9.
A case of erythema in a 'flagellate' pattern due to administration of bleomycin in a patient with Hodgkin's disease is described. Emphasis is placed on the low dose of bleomycin administered--15 mg parenterally--and the short time interval between drug administration and beginning of symptoms: 24 h. The histopathological findings were consistent with a mechanism of inflammatory oncotaxis: the attraction of tumor cells by the skin perhaps due to the bleomycin accumulated and the trauma caused by scratching subsequent to pruritus.
本文描述了1例霍奇金病患者因使用博来霉素而出现“鞭毛状”皮疹的病例。重点在于博来霉素的给药剂量较低——胃肠外给药15mg，以及给药与症状出现之间的时间间隔较短：24小时。组织病理学检查结果与炎性肿瘤趋化机制一致：皮肤对肿瘤细胞的吸引可能是由于博来霉素的蓄积以及瘙痒后搔抓引起的创伤。
