Radkhah Hanieh, Maleki Saba, Arabzadeh Bahri Razman
Internal Medicine Department, School of Medicine, Sina Hospital Tehran University of Medical Sciences Tehran Iran.
School of Medicine Guilan University of Medical Sciences (GUMS) Rasht Guilan Province Iran.
Health Sci Rep. 2024 Dec 19;7(12):e70294. doi: 10.1002/hsr2.70294. eCollection 2024 Dec.
Serpentine supravenous hyperpigmentation (SSH) is known as a phenomenon occurring during the infusion of chemotherapy agents in the underlying veins. Chemotherapy agents have potential to cause infusion reactions when used systematically. Linear hyperpigmentation and reticular hyperpigmentation are the differential diagnosis for this phenomenon. The aim of the present study was to systematically review the serpentine supravenous dermatitis induced by chemotherapeutic agents.
A comprehensive search was conducted in Scopus, PubMed, Embase, and Web of Science bibliometric databases on February 7, 2023. The search keywords were categorized into two groups: SSH and chemotherapy. Any combination between keywords was used for the systematic search. We included any type of article that evaluated the SSH in cancer patients after the infusion of chemotherapeutic agents, including observational studies with at least one eligible patient based on our criteria, case series, and case reports. Studies that reported SSH in non-cancer patients or caused by any medications other than chemotherapeutic agents were excluded.
Twenty-five studies were included based on our inclusion criteria consisting of 26 patients. A total of 13 different cancers were reported in the included studies. Lung cancer was the most reported cancer. Also, the mostly reported region of this dermatitis was forearm which was reported in 13 studies. Docetaxel has been used in a total of 11 articles in this study and has independently induced serpentine supravenous dermatitis in seven studies, which is the mostly reported chemotherapeutic agent resulting into serpentine supravenous dermatitis. Most of these skin lesions were self-limiting and with a normal histopathological finding.
SSH is a dermatologic reaction, which mostly occur when there is peripheral venous access for the injection of chemotherapeutic agents. The skin lesion will improve spontaneously and have a benign course with no abnormal histopathological pathological finding.
蛇形静脉上色素沉着（SSH）是指在化疗药物经皮下静脉输注过程中出现的一种现象。化疗药物全身应用时可能引发输注反应。线性色素沉着和网状色素沉着是该现象的鉴别诊断。本研究旨在系统评价化疗药物所致的蛇形静脉上皮炎。
于2023年2月7日在Scopus、PubMed、Embase和Web of Science文献计量数据库中进行全面检索。检索关键词分为两组：SSH和化疗。关键词之间的任何组合均用于系统检索。我们纳入了任何评估化疗药物输注后癌症患者SSH的文章类型，包括根据我们的标准至少有一名合格患者的观察性研究、病例系列和病例报告。排除报告非癌症患者SSH或由化疗药物以外的任何药物引起的SSH的研究。
根据纳入标准纳入了25项研究，共26例患者。纳入研究中报告了总共13种不同的癌症。肺癌是报告最多的癌症。此外，该皮炎最常报告的部位是前臂，13项研究中有报告。本研究中共有11篇文章使用了多西他赛，其中7项研究独立诱发了蛇形静脉上皮炎，是导致蛇形静脉上皮炎报告最多的化疗药物。这些皮肤病变大多为自限性，组织病理学检查结果正常。
SSH是一种皮肤反应，主要发生在有外周静脉通路用于注射化疗药物时。皮肤病变会自发改善，病程良性，组织病理学检查无异常发现。
