Fujiki Minoru, Hikawa Takamitsu, Abe Tatsuya, Ishii Keisuke, Kobayashi Hidenori
Department of Neurosurgery, School of Medicine, Oita University, 1-1 Idaigaoka, Hasamamach, Oita 879-5593, Japan.
Neurosci Lett. 2006 Sep 25;405(3):226-30. doi: 10.1016/j.neulet.2006.07.005. Epub 2006 Aug 9.
The present study used short interval intracortical inhibition (SICI), intracortical facilitation (ICF), and short latency afferent inhibition (SAI) to evaluate motor cortex excitability in 16 diffuse axonal injury (DAI) patients with memory impairment and compared the data with those of 16 healthy controls. SAI was reduced in patients compared with controls (92+/-12 versus 39+/-11% of the test size; p<0.0001, unpaired t-test). DAI patients tended to have a high resting motor threshold (RMT) and less pronounced SICI and ICF than controls, but these differences were not significant. A single oral dose (3mg) of donepezil, an acetylcholinesterase inhibitor that is commonly used to treat Alzheimer's disease (AD), improved SAI in DAI patients with wide individual variations that ranged from an increase of 77-18% of test size. These findings suggest that measuring SAI may provide a means of probing the integrity of cholinergic networks in an injured human brain.
本研究采用短间隔皮质内抑制（SICI）、皮质内易化（ICF）和短潜伏期传入抑制（SAI）来评估16例患有记忆障碍的弥漫性轴索损伤（DAI）患者的运动皮质兴奋性，并将数据与16名健康对照者的数据进行比较。与对照组相比，患者的SAI降低（测试大小的92±12%对39±11%；p<0.0001，非配对t检验）。DAI患者的静息运动阈值（RMT）往往较高，SICI和ICF不如对照组明显，但这些差异不显著。单剂量口服（3mg）多奈哌齐，一种常用于治疗阿尔茨海默病（AD）的乙酰胆碱酯酶抑制剂，改善了DAI患者的SAI，个体差异较大，测试大小增加范围为77%-18%。这些发现表明，测量SAI可能提供一种探究受伤人脑胆碱能网络完整性的方法。
