Chrysohoou Christina, Panagiotakos Demosthenes B, Pitsavos Christos, Skoumas Ioannis, Papademetriou Lambros, Economou Manolis, Stefanadis Christodoulos
First Cardiology Clinic, School of Medicine, University of Athens, Athens, Greece.
Nutr Metab Cardiovasc Dis. 2007 Oct;17(8):590-7. doi: 10.1016/j.numecd.2006.05.007. Epub 2006 Aug 9.
We evaluated the association of obesity with serum total antioxidant capacity (TAC), in a population-based sample of 3042 adults.
During 2001-2002 we randomly enrolled 1514 men (18-87 years old) and 1528 women (18-89 years old), from the Attica area in Greece into the study, and the sample was stratified by the age-sex distribution of the region (census 2001). Among several variables we also measured serum TAC and weight, height, waist and hip circumferences. Waist circumference greater than 102 cm for men and 88 cm for women was considered an indicator of central fat.
Mean waist circumference was 98+/-13 cm in men and 84+/-22 cm in women (P<0.001), while mean hip circumference was 106+/-28 cm in men and 103+/-13 cm in women (P<0.001). Central fat prevailed in 53% of men and 45% of women (P<0.001). Male participants with central fat exhibited 5% lower TAC concentrations compared to leaner individuals (214+/-35 vs. 226+/-33 micromol/L, P=0.04) and female participants with central fat exhibited 7% lower TAC concentrations (256+/-38 vs. 239+/-27 micromol/L, P=0.03). Similarly, obese or overweight male participants had 6% lower TAC concentrations compared to normal weight (217+/-33 vs. 234+/-39 micromol/L, P=0.03) and female obese or overweight participants had 10% lower TAC concentrations (226+/-32 vs. 250+/-30 micromol/L, P=0.02) compared to the others.
Our results suggest an inverse relationship between body fat, central adiposity and antioxidant capacity, irrespective of age and various other potential confounders, namely smoking, physical activity, dietary habits, blood pressure, glucose levels, and lipid concentrations.
我们在一个包含3042名成年人的基于人群的样本中，评估了肥胖与血清总抗氧化能力（TAC）之间的关联。
在2001 - 2002年期间，我们从希腊阿提卡地区随机招募了1514名男性（18 - 87岁）和1528名女性（18 - 89岁）参与研究，样本根据该地区的年龄 - 性别分布（2001年人口普查数据）进行分层。在多个变量中，我们还测量了血清TAC以及体重、身高、腰围和臀围。男性腰围大于102厘米、女性腰围大于88厘米被视为中心性肥胖的指标。
男性平均腰围为98±13厘米，女性为84±22厘米（P<0.001），而男性平均臀围为106±28厘米，女性为103±13厘米（P<0.001）。53%的男性和45%的女性存在中心性肥胖（P<0.001）。与体型较瘦的个体相比，存在中心性肥胖的男性参与者的TAC浓度低5%（214±35对226±33微摩尔/升，P = 0.04），存在中心性肥胖的女性参与者的TAC浓度低7%（256±38对239±27微摩尔/升，P = 0.03）。同样，与正常体重者相比，肥胖或超重的男性参与者的TAC浓度低6%（217±33对234±39微摩尔/升，P = 0.03），肥胖或超重的女性参与者的TAC浓度低10%（226±32对250±30微摩尔/升，P = 0.02）。
我们的结果表明，无论年龄以及其他各种潜在混杂因素（即吸烟、身体活动、饮食习惯、血压、血糖水平和血脂浓度）如何，体脂、中心性肥胖与抗氧化能力之间存在负相关关系。
