取代的5-苄基-2-苯基-5H-咪唑并[4,5-c]吡啶：一类新型的瘟病毒抑制剂。
Substituted 5-benzyl-2-phenyl-5H-imidazo[4,5-c]pyridines: a new class of pestivirus inhibitors.
作者信息
Puerstinger Gerhard, Paeshuyse Jan, Herdewijn Piet, Rozenski Jef, De Clercq Erik, Neyts Johan
机构信息
Institut für Pharmazie, Abteilung Pharmazeutische Chemie, Universität Innsbruck, Innrain 52a, A-6020 Innsbruck, Austria.
出版信息
Bioorg Med Chem Lett. 2006 Oct 15;16(20):5345-9. doi: 10.1016/j.bmcl.2006.07.081. Epub 2006 Aug 9.
PMID:16901692
Abstract
A novel class of inhibitors of pestiviruses (5-substituted 2-phenyl-5H-imidazo[4,5-c]pyridines) is described. Modification of the substituent in position 5 resulted in analogues with high activity (EC(50)<100nM) and selectivity (SI>1000) against the pestivirus BVDV (bovine viral diarrhea virus).
摘要
描述了一类新型的瘟病毒抑制剂（5-取代的2-苯基-5H-咪唑并[4,5-c]吡啶）。5位取代基的修饰产生了对瘟病毒牛病毒性腹泻病毒（BVDV）具有高活性（EC50<100nM）和选择性（SI>1000）的类似物。
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