Shibata Yoko, Voeltz Gia K, Rapoport Tom A
Howard Hughes Medical Institute and Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
Cell. 2006 Aug 11;126(3):435-9. doi: 10.1016/j.cell.2006.07.019.
The endoplasmic reticulum (ER) has distinct morphological domains composed of sheets and tubules, which differ in their characteristic membrane curvature. Key proteins may drive the formation of these structural morphologies, which in turn could generate the rough and smooth functional domains of the ER.
内质网(ER)具有由片层和小管组成的不同形态结构域,它们的特征性膜曲率不同。关键蛋白可能驱动这些结构形态的形成,而这些结构形态反过来又可能产生内质网的粗面和光面功能结构域。