Dale Colin, Moran Nancy A
Department of Biology, University of Utah, Salt Lake City, UT 84112, USA.
Cell. 2006 Aug 11;126(3):453-65. doi: 10.1016/j.cell.2006.07.014.
Symbiotic bacteria are important in animal hosts, but have been largely overlooked as they have proved difficult to culture in the laboratory. Approaches such as comparative genomics and real-time PCR have provided insights into the molecular mechanisms that underpin symbiont-host interactions. Studies on the heritable symbionts of insects have yielded valuable information about how bacteria infect host cells, avoid immune responses, and manipulate host physiology. Furthermore, some symbionts use many of the same mechanisms as pathogens to infect hosts and evade immune responses. Here we discuss what is currently known about the interactions between bacterial symbionts and their hosts.
共生细菌在动物宿主中很重要，但由于在实验室中难以培养，它们在很大程度上被忽视了。比较基因组学和实时PCR等方法为共生体与宿主相互作用的分子机制提供了见解。对昆虫可遗传共生体的研究产生了关于细菌如何感染宿主细胞、避免免疫反应以及操纵宿主生理的宝贵信息。此外，一些共生体利用许多与病原体相同的机制来感染宿主并逃避免疫反应。在这里，我们讨论目前已知的细菌共生体与其宿主之间的相互作用。
