激素疗法治疗雌激素受体α阳性的乳腺外佩吉特病。

Estrogen-receptor-alpha-positive extramammary Paget's disease treated with hormonal therapy.

作者信息

Iijima M, Uhara H, Ide Y, Sakai S, Onuma H, Muto M, Hayashi K, Mitsura F, Kobayashi S, Yoshizawa A, Saida T

机构信息

Department of Dermatology, Shinshu University School of Medicine, Matsumoto, Japan.

出版信息

Dermatology. 2006;213(2):144-6. doi: 10.1159/000093854.

DOI:10.1159/000093854

PMID:16902292

Abstract

The patient was an 80-year-old man with scrotal and penile extramammary Paget's disease and prostate cancer. Both diseases were in advanced stages. Tumor cells of extramammary Paget's disease strongly expressed estrogen receptor alpha. The patient was concurrently treated with two kinds of hormonal therapy: the anti-estrogen tamoxifen (20 mg/day orally) for extramammary Paget's disease and the anti-androgen bicalutamide (80 mg/day orally) for prostate cancer. The toxicity of the therapy was mild. All of the metastatic lesions remained stable for 2 months after initiation of dual hormonal therapy. During a follow-up period of 22 months, performance status was well maintained for 17 months. Hormonal therapy may be an alternative for selected cases of advanced extramammary Paget's disease.

摘要

该患者为一名80岁男性，患有阴囊和阴茎部的乳腺外佩吉特病及前列腺癌。两种疾病均处于晚期。乳腺外佩吉特病的肿瘤细胞强烈表达雌激素受体α。该患者同时接受两种激素治疗：用于乳腺外佩吉特病的抗雌激素他莫昔芬（口服20毫克/天）和用于前列腺癌的抗雄激素比卡鲁胺（口服80毫克/天）。治疗的毒性较轻。开始双重激素治疗后，所有转移病灶在2个月内保持稳定。在22个月的随访期内，患者的身体状况良好维持了17个月。激素治疗可能是晚期乳腺外佩吉特病特定病例的一种替代治疗方法。