Roumy Vincent, Fabre Nicolas, Souard Florence, Massou Stéphane, Bourdy Geneviève, Maurel Séverine, Valentin Alexis, Moulis Claude
Laboratoire Pharmacochimie des Substances Naturelles et Pharmacophores Redox, UMR 152 IRD, Université Toulouse 3 Paul Sabatier, Faculté des Sciences Pharmaceutiques, Toulouse, France.
Planta Med. 2006 Aug;72(10):894-8. doi: 10.1055/s-2006-947184. Epub 2006 Aug 10.
A novel and very unusual azaanthracene alkaloid, 1-aza-7,8,9,10-tetramethoxy-4-methyl-2-oxo-1,2-dihydroanthracene ( 1) and a new diastereoisomer of the bis-benzylisoquinoline alkaloid rodiasine, 1 S,1' R-rodiasine ( 2), as well as the alkaloids O-methylpunjabine ( 3) and O-methylmoschatoline ( 4) have been isolated from Pseudoxandra cuspidata bark, used in French Guiana as an antimalarial. Their structures were elucidated by spectroscopic analyses, especially 2D-NMR techniques (ADEQUATE and NOESY). We found that the antimalarial activity of this bark was mostly due to bis-benzylisoquinoline 1 S,1' R-rodiasine ( 2) (IC (50)= 1 microM) also displaying a low cytotoxicity.
从圭亚那用于抗疟疾的尖叶假黄肉楠树皮中分离出了一种新型且非常罕见的氮杂蒽生物碱1-氮杂-7,8,9,10-四甲氧基-4-甲基-2-氧代-1,2-二氢蒽（1）、双苄基异喹啉生物碱罗迪亚辛的一种新的非对映异构体1S,1'R-罗迪亚辛（2）以及生物碱O-甲基旁遮普碱（3）和O-甲基莫沙托林（4）。通过光谱分析，尤其是二维核磁共振技术（全相关谱和核Overhauser效应谱）阐明了它们的结构。我们发现该树皮的抗疟疾活性主要归因于双苄基异喹啉1S,1'R-罗迪亚辛（2）（半数抑制浓度=1微摩尔），其细胞毒性也较低。
