School of Science, University of Phayao, Maeka, Muang, Phayao 56000, Thailand.
J Nat Prod. 2013 Apr 26;76(4):723-6. doi: 10.1021/np3006937. Epub 2013 Apr 8.
Chemical investigation of an alkaloidal extract of Alstonia macrophylla bark led to the isolation and identification of two new nitrogenous derivatives, alstoniaphyllines A (1) and B (2), a new indole alkaloid, alstoniaphylline C (4), and eight known alkaloids (3, 5-11). Alstonisine (9) exhibited antiplasmodial activity against Plasmodium falciparum, with an IC50 of 7.6 μM.
从马达加斯加萝芙木 Alstonia macrophylla 树皮的生物碱提取物中分离得到两个新的含氮衍生物，即 alstoniaphyllines A（1）和 B（2）、一个新的吲哚生物碱 alstoniaphylline C（4）和八个已知生物碱（3、5-11）。Alstonisine（9）对恶性疟原虫 Plasmodium falciparum 表现出抗疟活性，IC50 为 7.6 μM。
