Li Bin, Samanta Arabinda, Song Xiaomin, Furuuchi Keiji, Iacono Kathryn T, Kennedy Sarah, Katsumata Makoto, Saouaf Sandra J, Greene Mark I
Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104-6082, USA.
Immunol Rev. 2006 Aug;212:99-113. doi: 10.1111/j.0105-2896.2006.00405.x.
Our recent studies have identified dynamic protein ensembles containing forkhead box protein 3 (FOXP3) that provide insight into the molecular complexity of suppressor T-cell activities, and it is our goal to determine how these ensembles regulate FOXP3's transcriptional activity in vivo. In this review, we summarize our current understanding of how FOXP3 expression is induced and how FOXP3 functions in vivo as a transcriptional regulator by assembling a multisubunit complex involved in histone modification as well as chromatin remodeling.
我们最近的研究发现了包含叉头框蛋白3（FOXP3）的动态蛋白质复合体，这为深入了解抑制性T细胞活动的分子复杂性提供了线索，我们的目标是确定这些复合体如何在体内调节FOXP3的转录活性。在这篇综述中，我们总结了目前对FOXP3表达如何被诱导以及FOXP3作为转录调节因子在体内如何通过组装参与组蛋白修饰和染色质重塑的多亚基复合体发挥作用的理解。
