Department of Breast Surgery, Obstetrics and Gynecology Hospital, Fudan University School of Medicine, Shanghai, China.
Center for Immune-Related Diseases at Shanghai Institute of Immunology, Department of Respiratory and Critical Care Medicine of Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Front Immunol. 2022 Oct 13;13:982986. doi: 10.3389/fimmu.2022.982986. eCollection 2022.
FOXP3+ regulatory T (Treg) cells play critical roles in establishing the immunosuppressive tumour microenvironment, which is achieved and dynamically maintained with the contribution of various stromal and immune cell subsets. However, the dynamics of non-lymphoid FOXP3+ Treg cells and the mutual regulation of Treg cells and other cell types in solid tumour microenvironment remains largely unclear. In this review, we summarize the latest findings on the dynamic connections and reciprocal regulations of non-lymphoid Treg cell subsets in accordance with well-established and new emerging hallmarks of cancer, especially on the immune escape of tumour cells in solid tumours. Our comprehension of the interplay between FOXP3+ Treg cells and key hallmarks of cancer may provide new insights into the development of next-generation engineered T cell-based immune treatments for solid tumours.
FOXP3+ 调节性 T（Treg）细胞在建立免疫抑制性肿瘤微环境中发挥着关键作用，这一过程是通过各种基质和免疫细胞亚群的贡献来实现和动态维持的。然而，非淋巴源性 FOXP3+Treg 细胞的动态以及 Treg 细胞与实体瘤微环境中其他细胞类型的相互调节在很大程度上仍不清楚。在这篇综述中，我们总结了非淋巴源性 Treg 细胞亚群的动态联系和相互调节的最新发现，这些发现与癌症的既定和新出现的特征有关，特别是与实体瘤中肿瘤细胞的免疫逃逸有关。我们对 FOXP3+Treg 细胞与癌症关键特征之间相互作用的理解，可能为开发新一代基于工程 T 细胞的实体瘤免疫治疗提供新的思路。
