Both R, Mühlau G, Schmidt A
Klinik für Psychiatrie und Neurologie Hans Berger, Friedrich-Schiller-Universität Jena, DDR.
Schweiz Arch Neurol Psychiatr (1985). 1990;141(1):5-16.
A total of 189 patients underwent clinical, electromyographical and patho-anatomical examination (by muscle biopsy). 102 of the patients suffered from myopathy, 45 patients from neurogenic muscle diseases. 31 patients were suffering from chronic renal insufficiency and 11 patients from chronic alcoholism. The statistic elaboration of the findings was done by the multivariate analysis of variance (MANOVA) and discriminant analysis, in order to determine the diagnostic value of single parameters of investigation and to demonstrate diagnostically effective parameter combinations for diagnosing myopathies. Employing the discriminant function for the differentiation of myopathies and neurogenic muscle diseases yielded in patients with chronic renal insufficiency predominantly (30 cases) references to a neurogenic lesion of the proximal muscles and in the patients with chronic alcoholism relatively often (6 cases) references to a myogenic lesion of the proximal muscles.
共有189例患者接受了临床、肌电图和病理解剖学检查（通过肌肉活检）。其中102例患有肌病，45例患有神经源性肌肉疾病。31例患者患有慢性肾功能不全，11例患者患有慢性酒精中毒。为了确定各项检查参数的诊断价值，并展示用于诊断肌病的有效诊断参数组合，我们通过多变量方差分析（MANOVA）和判别分析对研究结果进行了统计学处理。运用判别函数区分肌病和神经源性肌肉疾病时，发现慢性肾功能不全患者中主要（30例）提示近端肌肉的神经源性病变，而慢性酒精中毒患者中相对常见（6例）提示近端肌肉的肌源性病变。
