Andrews J E, Gray L E
Developmental Toxicology Division, Health Research Laboratory, Research Triangle Park, NC 27711.
Toxicology. 1990 Jan-Feb;60(1-2):99-107. doi: 10.1016/0300-483x(90)90165-d.
Experiments were performed to investigate the effects of lindane and linuron on calcium metabolism, femur morphometry and nephrotoxicity. Long-Evans hooded rats were dosed daily for 10 weeks with 0, 10 or 20 mg lindane or 10, 20 or 40 mg linuron/kg body weight beginning at weaning. Lindane significantly decreased urinary calcium concentration, serum alkaline phosphatase concentration and the cross-sectional medullary area of the bone. Lindane was nephrotoxic at both dose levels as demonstrated by elevated kidney weights, kidney-to-body-weight ratios, urinary LDH, tubule regeneration and hyaline droplet degeneration. Linuron significantly reduced medullary cross-sectional area at the 2 higher dose levels and decreased the total femur cross-sectional area at the highest dose level in the absence of effects on calcium excretion. Femur density and strength were also significantly reduced at the highest dose level of linuron. Neither compound affected the serum concentrations of parathyroid hormone or 1,25-dihydroxy Vitamin D-3. Both linuron and lindane exposure significantly increased serum cholesterol concentrations and reduced serum triglyceride concentrations. Both compounds affected calcium metabolism and/or bone morphometry but possibly by different mechanisms since the effects were not the same.
进行了实验以研究林丹和利谷隆对钙代谢、股骨形态测量和肾毒性的影响。从断奶开始，Long-Evans 带帽大鼠每天按 0、10 或 20 mg 林丹或 10、20 或 40 mg 利谷隆/千克体重的剂量给药，持续 10 周。林丹显著降低了尿钙浓度、血清碱性磷酸酶浓度和骨的髓腔横截面积。林丹在两个剂量水平均具有肾毒性，表现为肾脏重量增加、肾重与体重之比升高、尿乳酸脱氢酶升高、肾小管再生和透明滴变性。利谷隆在较高的两个剂量水平显著降低了髓腔横截面积，在最高剂量水平降低了股骨总横截面积，而对钙排泄无影响。在利谷隆的最高剂量水平，股骨密度和强度也显著降低。两种化合物均未影响甲状旁腺激素或 1,25 - 二羟基维生素 D - 3 的血清浓度。林丹和利谷隆暴露均显著增加血清胆固醇浓度并降低血清甘油三酯浓度。两种化合物均影响钙代谢和/或骨形态测量，但可能通过不同机制，因为其影响并不相同。
